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zatebradine , CAS No.85175-67-3, Channel blocker of HCN1;Channel blocker of HCN2;Channel blocker of HCN3;Channel blocker of HCN4

Moligand™

CAS#: 85175-67-3
Formula: C₂₆H₃₆N₂O₅
Molecular Weight: 456.6
PubChem CID: 65637

Item Number

Z614949

Grouped product items
SKU	Size	Availability	Price	Qty
Z614949-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614949-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

HCN1 Channel blocker HCN2 Channel blocker HCN3 Channel blocker HCN4 Channel blocker

Basic Description

Synonyms	Zatebradine\|85175-67-3\|Zatebradine [INN]\|3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one\|CHEMBL69679\|TV27RY5876\|UL-FS-49 (free base);UL-FS-49CL (free base)\|Zatebradina\|Zatebradinum\|Zatebradinum [INN-L
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of HCN1;Channel blocker of HCN2;Channel blocker of HCN3;Channel blocker of HCN4

Associated Targets

HCN3 Tclin Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 1 Activities

Discover Target: HCN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HCN1 Tclin Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 1 Activities

Discover Target: HCN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HCN2 Tclin Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 1 Activities

Discover Target: HCN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HCN4 Tclin Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 2 Activities

Discover Target: HCN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one
INCHI	InChI=1S/C26H36N2O5/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29/h7-8,15-17H,6,9-14,18H2,1-5H3
InChi Key	KEDQCFRVSHYKLR-UHFFFAOYSA-N
Canonical SMILES	CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CCC3=CC(=C(C=C3)OC)OC
Isomeric SMILES	CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CCC3=CC(=C(C=C3)OC)OC
Alternate CAS	85175-67-3,91940-87-3 (hydrochloride)
PubChem CID	65637
MeSH Entry Terms	1,3,4,5-tetrahydro-7,8-dimethoxy-3-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylimino)propyl)-2H-3-benzazepin-2-one hydrochloride;UL-FS 49;UL-FS-49;zatebradine;zatebradine hydrochloride
Molecular Weight	456.6

PubChem CID

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

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