Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If(HCN channel) in sinoatrial node cells (EC50= 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50of 13.4μ
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Product Description
application：
Zatebradine hydrochloride has been used:
as an If blocker to study its effects on cardiomyocyte clusters (CMCs)
as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish
G2301214