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Zaurategrast - ≥99%, high purity , CAS No.455264-31-0, Inhibitor of integrin α4β1;Inhibitor of integrin α4β7;Inhibitor of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)

Moligand™
≥99%

CAS#: 455264-31-0
Formula: C₂₆H₂₅BrN₄O₃
Molecular Weight: 521.42
PubChem CID: 10186367

Item Number

Z126002

Grouped product items
SKU	Size	Availability	Price
Z126002-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$355.90
Z126002-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,602.90
Z126002-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,883.90

View related series

integrin α4β1 Inhibitor integrin α4β7 Inhibitor integrin，alpha 4 subunit (antigen CD49D，alpha 4 subunit of VLA-4 receptor) Inhibitor

Basic Description

Synonyms	Zaurategrast\|455264-31-0\|Zaurategrast [INN]\|(S)-3-(4-((2,7-Naphthyridin-1-yl)amino)phenyl)-2-((2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino)propanoic acid\|CT-7758\|(2S)-2-((2-Bromo-3-oxospiro(3.5)non-1-en-1-yl)amino)-3-(4-((2,7-naphthyridin-1-yl)amino)phenyl
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Zaurategrast(CDP-323) is an integrin inhibitor.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of integrin α4β1;Inhibitor of integrin α4β7;Inhibitor of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGA4 Tclin Integrin alpha-4 0 Activities

Discover Target: ITGA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB7 Tclin Integrin beta-7 0 Activities

Discover Target: ITGB7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB1 Tclin Integrin beta-1 0 Activities

Discover Target: ITGB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-[(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-[4-(2,7-naphthyridin-1-ylamino)phenyl]propanoic acid
INCHI	InChI=1S/C26H25BrN4O3/c27-21-22(26(23(21)32)10-2-1-3-11-26)31-20(25(33)34)14-16-4-6-18(7-5-16)30-24-19-15-28-12-8-17(19)9-13-29-24/h4-9,12-13,15,20,31H,1-3,10-11,14H2,(H,29,30)(H,33,34)/t20-/m0/s1
InChi Key	KYHVWHYLKOHLKA-FQEVSTJZSA-N
Canonical SMILES	C1CCC2(CC1)C(=C(C2=O)Br)NC(CC3=CC=C(C=C3)NC4=NC=CC5=C4C=NC=C5)C(=O)O
Isomeric SMILES	C1CCC2(CC1)C(=C(C2=O)Br)N[C@@H](CC3=CC=C(C=C3)NC4=NC=CC5=C4C=NC=C5)C(=O)O
PubChem CID	10186367
Molecular Weight	521.42

PubChem CID

10186367

CAS Registry No.

455264-31-0

ChEMBL Ligand

CHEMBL4303708

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice.

References

1. Davenport RJ, Munday JR. (2007) Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases?. Drug Discov Today, 12 (13-14): (569-76). [PMID:17631252]
2. Chanteux H, Staelens L, Mancel V, Gerin B, Boucaut D, Prakash C, Nicolas JM. (2015) Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist.. Drug Metab Dispos, 43 (9): (1381-91). [PMID:26153275]
3. Li H, Huang SY, Shi FH, Gu ZC, Zhang SG, Wei JF. (2018) α₄β₇ integrin inhibitors: a patent review.. Expert Opin Ther Pat, 28 (12): (903-917). [PMID:30444683]

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Zaurategrast - ≥99%, high purity , CAS No.455264-31-0, Inhibitor of integrin α4β1;Inhibitor of integrin α4β7;Inhibitor of integrin; alpha 4 subunit (antigen CD49D; alpha 4 subunit of VLA-4 receptor)

Basic Description

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

ITGA4 Tclin Integrin alpha-4 0 Activities

ITGB7 Tclin Integrin beta-7 0 Activities

ITGB1 Tclin Integrin beta-1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

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