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SKU | Size | Availability | Price | Qty |
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Z422183-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $182.90 |
Mixed potent, nonsteroidal ERα and ERβ ligand. Mycotoxin.
Synonyms | ZEARALENONE | 17924-92-4 | trans-Zearalenone | (-)-Zearalenone | Mycotoxin F2 | (S)-Zearalenone | Zenone | (S)-(-)-Zearalenone | (10S)-Zearalenone | C18H22O5 | (3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione | CHEBI:10106 | Com |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Zearalenone, a fungal mycotoxin produced by Fusarium, binds the estrogen receptor (ER) and is uterotropic in the newborn rat. It is a common contaminant in cereal grain used for animal and human food, and exerts an estrogenic activity that modulates/disru |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Zearalenone, a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. This agent has demonstrated the ability to induce apoptosis via activation of mitochondrial release of Cytochrome c, production of reactive oxygen species (ROS), activation of caspase-3 and caspase-8, and induction of endoplasmic reticulum stress. Additional studies suggest that Zearalenone also up-regulates Bax expression and down-regulates Bcl-xL expression in cells, which also contribute to a halt in cell proliferation. The cell growth arrests caused by this mycotoxin seem to take place during the G1 phase of the cell cycle. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (4S,12E)-16,18-dihydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione |
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INCHI | InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1 |
InChi Key | MBMQEIFVQACCCH-QBODLPLBSA-N |
Canonical SMILES | CC1CCCC(=O)CCCC=CC2=C(C(=CC(=C2)O)O)C(=O)O1 |
Isomeric SMILES | C[C@H]1CCCC(=O)CCC/C=C/C2=C(C(=CC(=C2)O)O)C(=O)O1 |
WGK Germany | 3 |
UN Number | 3261 |
Packing Group | I |
Molecular Weight | 318.36 |
Beilstein | 1350216 |
Enter Lot Number to search for COA:
Sensitivity | light sensitive |
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Flash Point(°F) | 42.8℉ |
Flash Point(°C) | 6°C |
Melt Point(°C) | 162 °C |
Pictogram(s) | GHS08, GHS05 |
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Signal | Danger |
Hazard Statements | H314:Causes severe skin burns and eye damage H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P203:Obtain, read and follow all safety instructions before use. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. |
WGK Germany | 3 |
Class | 8 |
1. Ting Wang, Ting Zhou, Kang Wu, Junlin Cao, Yuze Feng, Jianguo Li, Anping Deng. (2024) A sensitive monoclonal antibody-based ELISA integrated with immunoaffinity column extraction for the detection of zearalenone in food and feed samples. ANALYST, 149 (2): (442-450). [PMID:38099486] [10.1039/D3AN01779F] |
2. Wenting Li, Yongqiang Shi, Xinai Zhang, Xuetao Hu, Xiaowei Huang, Nini Liang, Tingting Shen, Xiaobo Zou, Jiyong Shi. (2024) A DNA tetrahedral scaffolds-based electrochemical biosensor for simultaneous detection of AFB1 and OTA. FOOD CHEMISTRY, 442 (138312). [PMID:38219562] [10.1016/j.foodchem.2023.138312] |
3. Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma. (2023) 3D plasmonic SERS aptasensor for rapid detection of aflatoxin B1 combined with Au@Ag bimetallic nanostars and Fe3O4@MoS2 magnetic nanoflowers. MICROCHEMICAL JOURNAL, (109598). [PMID:14728084] [10.1016/j.microc.2023.109598] |
4. Yumeng Liao, Nan Zhang, Danni Chai, Boshi Liu, Jingrong Li, Yuting Fang, Di Zhang, Rui Liu, Zheng Li. (2023) Rational design of ratiometric fluorescent aptasensor for patulin in traditional Chinese medicine through the studies of interaction mechanism between DNA aptamer and target molecule. ANALYST, (3): [PMID:37725068] [10.1039/D3AN00923H] |
5. Ziyang He, Jinxin Zhang, Mei Liu, Yonghong Meng. (2024) Polyvalent aptamer scaffold coordinating light-responsive oxidase-like nanozyme for sensitive detection of zearalenone. FOOD CHEMISTRY, 431 (136908). [PMID:37573743] [10.1016/j.foodchem.2023.136908] |
6. Xuecheng Liu, Ragini Singh, Guoru Li, Carlos Marques, Bingyuan Zhang, Santosh Kumar. (2023) WaveFlex Biosensor-using Novel Tri-Tapered in Tapered Four-Core Fiber with Multimode Fiber Coupling for Detection of Aflatoxin B1. JOURNAL OF LIGHTWAVE TECHNOLOGY, PP (99): (1-10). [PMID:] [10.1109/JLT.2023.3301069] |
7. Yexuan Ren, Ruwen Tian, Ting Wang, Junlin Cao, Jianguo Li, Anping Deng. (2023) An Extremely Highly Sensitive ELISA in pg mL−1 Level Based on a Newly Produced Monoclonal Antibody for the Detection of Ochratoxin A in Food Samples. MOLECULES, 28 (15): (5743). [PMID:37570711] [10.3390/molecules28155743] |
8. Guo Ge, Tianlin Wang, Zihou Liu, Xiaomeng Liu, Tiange Li, Yuntang Chen, Jialin Fan, Erkigul Bukye, Xianqing Huang, Lianjun Song. (2023) A self-assembled DNA double-crossover-based fluorescent aptasensor for highly sensitivity and selectivity in the simultaneous detection of aflatoxin M1 and aflatoxin B1. TALANTA, 265 (124908). [PMID:37442003] [10.1016/j.talanta.2023.124908] |
9. Xiaobing Yang, Junjie Pan, Jiapeng Hu, Shengyun Zhao, Kejun Cheng. (2023) MOF-derived La–ZnFe2O4@Fe3O4@carbon magnetic hybrid composite as a highly efficient and recyclable photocatalyst for mycotoxins degradation. CHEMICAL ENGINEERING JOURNAL, 467 (143381). [PMID:] [10.1016/j.cej.2023.143381] |
10. Sai Zhang, Yahui Wang, Qinglin Sheng, Tianli Yue. (2023) Electrochemical Aptasensor Based on ZnO-Au Nanocomposites for the Determination of Ochratoxin A in Wine and Beer. Processes, 11 (3): (864). [PMID:] [10.3390/pr11030864] |
11. Qingxin Zhang, Manru Zhang, Zhiqiang Guo, Jingjing Li, Zhixue Zhu, Yu Wang, Su Liu, Jiadong Huang, Jinghua Yu. (2023) DNA tetrahedron-besieged primer and DNAzyme-activated programmatic RCA for low-background electrochemical detection of ochratoxin A. ANALYTICA CHIMICA ACTA, 1242 (340782). [PMID:36657887] [10.1016/j.aca.2023.340782] |
12. Zhu Jing, Xu Wenxing, Yang Ye, Kong Rongmei, Wang Junmei. (2023) ssDNA-C3N4 conjugates-based nanozyme sensor array for discriminating mycotoxins. MICROCHIMICA ACTA, 190 (1): (1-10). [PMID:36471087] [10.1007/s00604-022-05593-y] |
13. Dongyan Li, Huaiyue Xia, Yingying Sun, Wenjie Liu, Wen Liu, Jianna Yu, Guoxing Jing, Jian Zhang, Wenshan Li. (2023) Colorimetric aptasensor for the sensitive detection of ochratoxin A based on a triple cascade amplification strategy. ANALYTICA CHIMICA ACTA, 1237 (340616). [PMID:36442942] [10.1016/j.aca.2022.340616] |
14. Yongmei Jia, Qiuxia Lai, Zhiguo Li, Guohua Zhou, Peilian Liu, Xunbo Lu, Mingyue Xue, Yong Cheng. (2022) Construction of AIEgens and graphene oxide based aptasensor with two-fluorescent signals for determination of Aflatoxin B1 in food Samples. GIANT, 12 (100132). [PMID:] [10.1016/j.giant.2022.100132] |
15. Pengfei Wang, Bin Luo, Ke Liu, Cheng Wang, Hongtu Dong, Xiaodong Wang, Peichen Hou, Aixue Li. (2022) A novel COOH–GO–COOH–MWNT/pDA/AuNPs based electrochemical aptasensor for detection of AFB1. RSC Advances, 12 (43): (27940-27947). [PMID:36320289] [10.1039/D2RA03883H] |
16. Kemin Shen, Xiaoqin Hu, Linlin Sun, Chun Han, Jianzhou Yang. (2022) Development of a Lateral Flow Strip with a Positive Readout for the On-Site Detection of Aflatoxin B1. MOLECULES, 27 (15): (4949). [PMID:35956902] [10.3390/molecules27154949] |
17. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [PMID:] [10.1080/09540105.2022.2080188] |
18. Mei Liu, Jinxin Zhang, Shasha Liu, Baoxin Li. (2022) A label-free visual aptasensor for zearalenone detection based on target-responsive aptamer-cross-linked hydrogel and color change of gold nanoparticles. FOOD CHEMISTRY, 389 (133078). [PMID:35490524] [10.1016/j.foodchem.2022.133078] |
19. Gao Huihui, Lu Dan, Xing Mingyan, Xu Qing, Xue Feng. (2022) Excavation, expression, and functional analysis of a novel zearalenone-degrading enzyme. FOLIA MICROBIOLOGICA, 67 (4): (633-640). [PMID:35349103] [10.1007/s12223-022-00967-4] |
20. Huang Hao, Camarada María Belén, Wang Dan, Liao Xiaoning, Xiong Wanming, Du Juan, Xiong Jianhua, Hong Yanping. (2022) MoS2 quantum dots and titanium carbide co-modified carbon nanotube heterostructure as electrode for highly sensitive detection of zearalenone. MICROCHIMICA ACTA, 189 (1): (1-13). [PMID:34873654] [10.1007/s00604-021-05104-5] |
21. Zhang Xue, Liao Xiaoning, Wu Yongfa, Xiong Wanming, Du Juan, Tu Zhui, Yang Wuying, Wang Dan. (2022) A sensitive electrochemical immunosensing interface for label-free detection of aflatoxin B1 by attachment of nanobody to MWCNTs-COOH@black phosphorene. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (2): (1129-1139). [PMID:34719746] [10.1007/s00216-021-03738-1] |
22. Chengxi Zhu, Dong Liu, Yuye Li, Ting Chen, Tianyan You. (2022) Label-free ratiometric homogeneous electrochemical aptasensor based on hybridization chain reaction for facile and rapid detection of aflatoxin B1 in cereal crops. FOOD CHEMISTRY, 373 (131443). [PMID:34742048] [10.1016/j.foodchem.2021.131443] |
23. Xiaoyuan Ma, Baoyi Shao, Zhouping Wang. (2021) Gold@silver nanodumbbell based inter-nanogap aptasensor for the surface enhanced Raman spectroscopy determination of ochratoxin A. ANALYTICA CHIMICA ACTA, 1188 (339189). [PMID:34794565] [10.1016/j.aca.2021.339189] |
24. Xueting Wang, Juping Liu, Kaiyue Zhang, Xin Yao, Shijuan Zhang. (2021) Analysis of mycotoxins in grain samples using 3D covalent organic frameworks and stable isotope labeling technique. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, [PMID:] [10.1080/10826076.2022.2066689] |
25. Hualin Guo, Yuhan Sun, Pengfei Ma, Imran Mahmood Khan, Nuo Duan, Zhouping Wang. (2022) Sensitive detection of patulin based on DNase Ⅰ-assisted fluorescent aptasensor by using AuNCs-modified truncated aptamer. FOOD CONTROL, 131 (108430). [PMID:] [10.1016/j.foodcont.2021.108430] |
26. Kunxia Li, Xiujuan Qiao, Haiyan Zhao, Yaping He, Qinglin Sheng, Tianli Yue. (2021) Ultrasensitive and label-free electrochemical aptasensor based on carbon dots-black phosphorus nanohybrid for the detection of Ochratoxins A. MICROCHEMICAL JOURNAL, 168 (106378). [PMID:] [10.1016/j.microc.2021.106378] |
27. Feng Wang, Zhen-Feng Li, De-Bin Wan, Natalia Vasylieva, Yu-Dong Shen, Zhen-Lin Xu, Jin-Yi Yang, Jan Gettemans, Hong Wang, Bruce D. Hammock, Yuan-Ming Sun. (2021) Enhanced Non-Toxic Immunodetection of Alternaria Mycotoxin Tenuazonic Acid Based on Ferritin-Displayed Anti-Idiotypic Nanobody-Nanoluciferase Multimers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (16): (4911–4917). [PMID:33870684] [10.1021/acs.jafc.1c01128] |
28. Jinxin Chi, Dandan Zhu, Yiqiong Chen, Guihua Huang, Xucong Lin. (2021) Online specific recognition of mycotoxins using aptamer-grafted ionic affinity monolith with mixed-mode mechanism. JOURNAL OF CHROMATOGRAPHY A, 1639 (461930). [PMID:33556780] [10.1016/j.chroma.2021.461930] |
29. Yeru Wang, Yu Wang, Su Liu, Wenyu Sun, Manru Zhang, Long Jiang, Minghan Li, Jinghua Yu, Jiadong Huang. (2021) Toehold-mediated DNA strand displacement-driven super-fast tripedal DNA walker for ultrasensitive and label-free electrochemical detection of ochratoxin A. ANALYTICA CHIMICA ACTA, 1143 (21). [PMID:33384119] [10.1016/j.aca.2020.11.013] |
30. Han Fu, Junping Liu, Wu Xu, Haixiang Wang, Shenghua Liao, Guitang Chen. (2020) A new type of magnetic molecular imprinted material combined with β-cyclodextrin for the selective adsorption of zearalenone. Journal of Materials Chemistry B, 8 (48): (10966-10976). [PMID:33185219] [10.1039/D0TB02146F] |
31. Bing Han, Cheng Fang, Lingjun Sha, Mohammed Jalalah, M.S. Al-Assiri, Farid A. Harraz, Ya Cao. (2021) Cascade strand displacement reaction-assisted aptamer-based highly sensitive detection of ochratoxin A. FOOD CHEMISTRY, 338 (127827). [PMID:32822900] [10.1016/j.foodchem.2020.127827] |
32. Feng Wang, Zhen-Feng Li, Yuan-Yuan Yang, De-Bin Wan, Natalia Vasylieva, Yu-Qi Zhang, Jun Cai, Hong Wang, Yu-Dong Shen, Zhen-Lin Xu, Bruce D. Hammock. (2020) Chemiluminescent Enzyme Immunoassay and Bioluminescent Enzyme Immunoassay for Tenuazonic Acid Mycotoxin by Exploitation of Nanobody and Nanobody–Nanoluciferase Fusion. ANALYTICAL CHEMISTRY, 92 (17): (11935–11942). [PMID:32702970] [10.1021/acs.analchem.0c02338] |
33. Hongjun Fang, Yusong Pan, Haixian Yan, Xiulong Qin, Chao Wang, Linfeng Xu, Chengling Pan. (2020) Facile preparation of Yb3+/Tm3+ co-doped Ti3C2/Ag/Ag3VO4 composite with an efficient charge separation for boosting visible-light photocatalytic activity. APPLIED SURFACE SCIENCE, 527 (146909). [PMID:] [10.1016/j.apsusc.2020.146909] |
34. Xiaoya Bi, Lijun Luo, Libo Li, Xiaohong Liu, Bainian Chen, Tianyan You. (2020) A FRET-based aptasensor for ochratoxin A detection using graphitic carbon nitride quantum dots and CoOOH nanosheets as donor-acceptor pair. TALANTA, 218 (121159). [PMID:32797913] [10.1016/j.talanta.2020.121159] |
35. Yafei Chen, Yajie Yang, Yu Wang, Ye Peng, Jinmei Nie, Guanyue Gao, Jinfang Zhi. (2020) Development of an Escherichia coli-based electrochemical biosensor for mycotoxin toxicity detection. BIOELECTROCHEMISTRY, 133 (107453). [PMID:31972449] [10.1016/j.bioelechem.2019.107453] |
36. Yanhua He, Youwei Yu, Xiaoye Wen, Yan Shi, Jianhu Wu, Zhengping Guan, Meilin Cui, Chunling Xiao. (2020) A quencher-free 2-aminopurine modified hairpin aptasensor for ultrasensitive detection of Ochratoxin A. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 228 (117780). [PMID:31753651] [10.1016/j.saa.2019.117780] |
37. Liping Zhou, Hao Hu, Yi-Xin Zhang, Qing-Ye Meng, Bing Yu, You-Qing Shen, Hai-Lin Cong. (2019) A Near-Infrared Triggered Intracellular pH Regulative PAMAM/O-nitrobenzaldehyde Coated UCNPs for Cancer Therapy. INTEGRATED FERROELECTRICS, [PMID:] [10.1080/10584587.2019.1592601] |
38. Xinglin Wang, Xiaoyi Gao, Jiale He, Xiaochen Hu, Yunchao Li, Xiaohong Li, Louzhen Fan, Hua-Zhong Yu. (2019) Systematic truncating of aptamers to create high-performance graphene oxide (GO)-based aptasensors for the multiplex detection of mycotoxins. ANALYST, 144 (12): (3826-3835). [PMID:31090762] [10.1039/C9AN00624A] |
39. Min Zhu, Xi Feng, Gaoyang Qiu, Jiayin Feng, Lujun Zhang, Phillip C. Brookes, Jianming Xu, Yan He. (2019) Synchronous response in methanogenesis and anaerobic degradation of pentachlorophenol in flooded soil. JOURNAL OF HAZARDOUS MATERIALS, 374 (258). [PMID:31005708] [10.1016/j.jhazmat.2019.04.040] |
40. He Deyun, Wu Zhengzong, Cui Bo, Xu Enbo, Jin Zhengyu. (2019) Building a Fluorescent Aptasensor Based on Exonuclease-Assisted Target Recycling Strategy for One-Step Detection of T-2 Toxin. Food Analytical Methods, 12 (2): (625-632). [PMID:] [10.1007/s12161-018-1392-x] |
1. Kunxia Li, Xiujuan Qiao, Haiyan Zhao, Yaping He, Qinglin Sheng*, Tianli Yue*. (2021) Ultrasensitive and label-free electrochemical aptasensor based on carbon dots-black phosphorus nanohybrid for the detection of Ochratoxins A. Microchemical Journal, 168 (-): (106378). [PMID:] [https://doi.org/10.1016/j.microc.2021.106378] |
2. Ting Wang, Ting Zhou, Kang Wu, Junlin Cao, Yuze Feng, Jianguo Li, Anping Deng. (2024) A sensitive monoclonal antibody-based ELISA integrated with immunoaffinity column extraction for the detection of zearalenone in food and feed samples. ANALYST, 149 (2): (442-450). [PMID:38099486] [10.1039/D3AN01779F] |
3. Wenting Li, Yongqiang Shi, Xinai Zhang, Xuetao Hu, Xiaowei Huang, Nini Liang, Tingting Shen, Xiaobo Zou, Jiyong Shi. (2024) A DNA tetrahedral scaffolds-based electrochemical biosensor for simultaneous detection of AFB1 and OTA. FOOD CHEMISTRY, 442 (138312). [PMID:38219562] [10.1016/j.foodchem.2023.138312] |
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