Zerumbone - 98%, high purity , CAS No.471-05-6

  • ≥98%
Item Number
Z275052
Grouped product items
SKUSizeAvailabilityPrice Qty
Z275052-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$48.90
Z275052-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$78.90
Z275052-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$355.90
Z275052-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$639.90

Potent NF-κB inhibitor. Anticancer agent.

Basic Description

SynonymsZerumbone | 471-05-6 | (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one | (E,E,E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one | CHEMBL245412 | 2E,6E,9E-humulatrien-8-one | CHEBI:63892 | erumbone | 2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one | SCHEM
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPotent NF-κB inhibitor. Anticancer agent. Induces cytochrome c dependent caspase activation and mitochondrial permeabilisation in cancer cells. Induces apoptosis and shows anti-inflammatory and antitumor effects in vivo. Orally active.
SourceZingiber officinale
Storage TempStore at 2-8°C,Protected from light
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Application:

Zerumbone has been used:

for liquid chromatography with mass spectrometry (LC-MS-MS)

to investigate its potential application in the prevention

treatment of esophageal squamous cell carcinomas (ESCC)

Associated Targets(Human)

GLI2 Tchem Zinc finger protein GLI2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW480 (6023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLI1 Tchem Zinc finger protein GLI1 (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLI2 Tchem Zinc finger protein GLI2 (13 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P338 (231 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
walK Sensor histidine kinase yycG (44 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one
INCHI InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+
InChi Key GIHNTRQPEMKFKO-SKTNYSRSSA-N
Canonical SMILES CC1=CCC(C=CC(=O)C(=CCC1)C)(C)C
Isomeric SMILES C/C/1=C\CC(/C=C/C(=O)/C(=C/CC1)/C)(C)C
PubChem CID 5470187
Molecular Weight 218.33

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot NumberCertificate TypeDateItem
L2205795Certificate of AnalysisSep 20, 2023 Z275052
L2205796Certificate of AnalysisSep 20, 2023 Z275052
L2205797Certificate of AnalysisSep 20, 2023 Z275052
L2205805Certificate of AnalysisSep 20, 2023 Z275052

Chemical and Physical Properties

SolubilitySoluble in DMSO to 25 mM
Sensitivitylight sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H317:May cause an allergic skin reaction

H400:Very toxic to aquatic life

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

Related Documents

Solution Calculators