Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Z275052-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $48.90 | |
Z275052-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $78.90 | |
Z275052-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $355.90 | |
Z275052-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $639.90 |
Potent NF-κB inhibitor. Anticancer agent.
Synonyms | C20262 | erumbone | BDBM50241296 | Zerumbone | MS-23207 | SCHEMBL12831266 | SRCZ-00151 | HB4130 | CCG-208558 | (E,E,E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one | NSC698299 | NSC-698299 | HY-N7015 | 2E,6E,9E-humulatrien-8-one | CS-0003365 | Zerumb |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Potent NF-κB inhibitor. Anticancer agent. Induces cytochrome c dependent caspase activation and mitochondrial permeabilisation in cancer cells. Induces apoptosis and shows anti-inflammatory and antitumor effects in vivo. Orally active. |
Source | Zingiber officinale |
Storage Temp | Store at 2-8°C,Protected from light |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Application: Zerumbone has been used: for liquid chromatography with mass spectrometry (LC-MS-MS) to investigate its potential application in the prevention treatment of esophageal squamous cell carcinomas (ESCC) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one |
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INCHI | InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+ |
InChi Key | GIHNTRQPEMKFKO-SKTNYSRSSA-N |
Canonical SMILES | CC1=CCC(C=CC(=O)C(=CCC1)C)(C)C |
Isomeric SMILES | C/C/1=C\CC(/C=C/C(=O)/C(=C/CC1)/C)(C)C |
PubChem CID | 5470187 |
Molecular Weight | 218.33 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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L2205805 | Certificate of Analysis | Sep 20, 2023 | Z275052 |
L2205795 | Certificate of Analysis | Nov 03, 2022 | Z275052 |
L2205796 | Certificate of Analysis | Nov 03, 2022 | Z275052 |
L2205797 | Certificate of Analysis | Nov 03, 2022 | Z275052 |
Solubility | Soluble in DMSO to 25 mM |
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Sensitivity | light sensitive |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H317:May cause an allergic skin reaction H400:Very toxic to aquatic life |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. |