Zibotentan (ZD4054) - ≥98%, high purity , Endothelin receptor ET-A antagonist, CAS No.186497-07-4, Endothelin receptor ET-A antagonist

Item Number

Z125040

• Synonyms: C19H16N6O4S | DB06629 | PDSP2_001599 | BROMPERIDOL DECANOATE [USP-RS] | Zibotentan [USAN:INN:JAN] | 3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)- | NCGC00242479-03 | 3-PYRIDINESULFONAMIDE, N-(3-METHOXY-5-METHYL
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resu
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Endothelin receptor ET-A antagonist
• Note: 250mg卖完停产，不再备货

Product Description

Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50 of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.