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TK:Tyrosine kinase
zidesamtinib , CAS No.Z614962, Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of neurotrophic receptor tyrosine kinase 1

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zidesamtinib , CAS No.Z614962, Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of neurotrophic receptor tyrosine kinase 1

Moligand™

PubChem CID: 166560233

Item Number

Z614962

Grouped product items
SKU	Size	Availability	Price	Qty
Z614962-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614962-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,390.90

View related series

c-ros oncogene 1，receptor tyrosine kinase Inhibitor neurotrophic receptor tyrosine kinase 1 Inhibitor

Basic Description

Synonyms	Zidesamtinib\|NVL-520\|2739829-00-4\|zidesamtinib [INN]\|MX5KQV5XHC\|NVL520\|SCHEMBL24007115\|GTPL12392\|EX-A8016\|Example 5 [US383715659]
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of neurotrophic receptor tyrosine kinase 1

Associated Targets

ROS1 Tclin Proto-oncogene tyrosine-protein kinase ROS 0 Activities

Discover Target: ROS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9-17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25)/t12-/m1/s1
InChi Key	DTWUUAFTYSMNQX-GFCCVEGCSA-N
Canonical SMILES	CCN1N=CC2=C1C3=CC(O[C@H](C)C4=CC(F)=CC=C4C5=NN(C)N=C5C2)=C(N)N=C3
Isomeric SMILES	CCN1C2=C(CC3=NN(N=C3C4=C(C=C(C=C4)F)[C@H](OC5=C(N=CC2=C5)N)C)C)C=N1
PubChem CID	166560233

Database links

PubChem CID	166560233

Certificates

Certificate of Analysis(COA)

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FAQs and Articles

FAQ

ROS1 Fusion Inhibitor NVL-520 with MGAT2 Inhibitor BMS-963272

Categories: Technical articles

Tags:

Building Blocks ROS1 inhibitor MGAT2 inhibitor Organic synthesis

References

1. Drilon A, Horan JC, Tangpeerachaikul A, Besse B, Ou SI, Gadgeel SM, Camidge DR, van der Wekken AJ, Nguyen-Phuong L, Acker A et al.. (2022) NVL-520 is a selective, TRK-sparing, and brain-penetrant inhibitor of ROS1 fusions and secondary resistance mutations.. Cancer Discov, 129 (3): (589-97). [PMID:36511802]

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