Zileuton is an orally active 5-LO (5-lipoxygenase) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Zileuton inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Arachidonate 5-lipoxygenase inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. A 5-LO (5-lipoxygenase) inhibitor.
1.Zouboulis ChC, Saborowski A, Boschnakow A. (2005) Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production.. Dermatology (Basel), 210 (1):(36-8). [PMID:15604543]
2.Malec J, Przybyszewski WM, Grabarczyk M, Sitarska E. (1984) Hydroxyurea has the capacity to induce damage to human erythrocytes which can be modified by radical scavengers.. Biochem Biophys Res Commun, 120 (2):(566-73). [PMID:6732772]
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G1917087