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Ziltivekimab (anti-IL-6) - Primary antibody, specific to IL6, >95%, high purity, Human IgG1, Antibody of Fc fragment of IgG receptor and transporter

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • Recombinant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Species reactivity(Reacts with): Human
  • Isotype: Human IgG1
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab175709
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab175709-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab175709-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90
Ab175709-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$739.90
Ab175709-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90
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Bulk Order  DATASHEET

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Accession#:P05231 Antibody Fc fragment of IgG receptor and transporter Antibody Gene ID:3569 IL6

Basic Description

Product NameZiltivekimab (anti-IL-6) - Primary antibody, specific to IL6, >95%, high purity, Human IgG1
SynonymsInterleukin BSF 2 antibody; B cell differentiation factor antibody; B cell stimulatory factor 2 antibody; B-cell stimulatory factor 2 antibody; BSF 2 antibody; BSF-2 antibody; BSF2 antibody; CDF antibody; CTL differentiation factor antibody; Cytotoxic T c
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityIL6
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeBINDING AGENT
Mechanism of actionAntibody of Fc fragment of IgG receptor and transporter
Product Description

Ziltivekimab (anti-IL-6) is a human anti-IL-6 monoclonal antibody that is effective in reducing serum CRP. Ziltivekimab (anti-IL-6) has anti-inflammatory activity and may be used in studies of chronic systemic inflammation and cardiovascular disease associated with CKD[1].

Product Properties

IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE26.4 kDa (Light Chain) & 49.7 kDa (Heavy Chain), under reducing conditions; 175.3 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS2226654-05-1

Images

Ziltivekimab (anti-IL-6) (Ab175709) - ELISA
Immobilized hu-IL-6 at 2 μg/mL can bind Ziltivekimab (anti-IL-6) (Ab175709) with the EC₅₀ of 103.3 ng/mL.

Ziltivekimab (anti-IL-6) (Ab175709) - SEC
The purity of Ziltivekimab (anti-IL-6) (Ab175709) is more than 95% verified by HPLC.

Associated Targets

FCGRT Tclin IgG receptor FcRn large subunit p51 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IL6 Tclin Interleukin-6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0404190Certificate of AnalysisApr 07, 2024 Ab175709
ZJ24F0404189Certificate of AnalysisApr 07, 2024 Ab175709
ZJ24F0404188Certificate of AnalysisApr 07, 2024 Ab175709

Related Documents

 SDS

 Specification Sheet

References

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18. Brakenhoff, J P JP, de Groot, E R ER, Evers, R F RF, Pannekoek, H H and Aarden, L A LA..  (1987)  Molecular cloning and expression of hybridoma growth factor in Escherichia coli..  Journal of immunology (Baltimore, Md. : 1950),    (15):   [PMID:3320204]
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20. May, L T LT, Helfgott, D C DC and Sehgal, P B PB..  (1986)  Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved..  Proceedings of the National Academy of Sciences of the United States of America,      [PMID:3538015]
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26. Fishman, D D and 6 more authors..  (1998)  The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis..  The Journal of clinical investigation,    (1):   [PMID:9769329]
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