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ZK 164015 - ≥99%(HPLC), high purity , CAS No.177583-70-9
Potent estrogen receptor antagonist
Basic Description Synonyms J-011295 | HMS3677K07 | HMS3413K07 | BRD-K05151076-001-01-8 | ZK164015 | ZK-164015 | DTXSID00430964 | Q27163881 | BDBM50474884 | 2-(4-hydroxyphenyl)-3-methyl-1-(10-pentylsulfonyldecyl)indol-5-ol | SCHEMBL7133598 | 2-(4-Hydroxyphenyl)-3-methyl-1-(10-(penty Specifications & Purity ≥99%(HPLC) Biochemical and Physiological Mechanisms Potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC50= 0.025μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cellsin vitro(IC50~ 1 nM). Storage Temp Room temperature Shipped In Normal
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-(4-hydroxyphenyl)-3-methyl-1-(10-pentylsulfonyldecyl)indol-5-ol INCHI InChI=1S/C30H43NO4S/c1-3-4-12-21-36(34,35)22-13-10-8-6-5-7-9-11-20-31-29-19-18-27(33)23-28(29)24(2)30(31)25-14-16-26(32)17-15-25/h14-19,23,32-33H,3-13,20-22H2,1-2H3 InChi Key LYJSJVYJLZOMCD-UHFFFAOYSA-N Canonical SMILES CCCCCS(=O)(=O)CCCCCCCCCCN1C2=C(C=C(C=C2)O)C(=C1C3=CC=C(C=C3)O)C Isomeric SMILES CCCCCS(=O)(=O)CCCCCCCCCCN1C2=C(C=C(C=C2)O)C(=C1C3=CC=C(C=C3)O)C PubChem CID 9806489 Molecular Weight 513.73
Chemical and Physical Properties Solubility Solvent:ethanol, Max Conc. mg/mL: 12.84, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 51.37, Max Conc. mM: 100
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