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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Z412413-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,809.90 | |
Z412413-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $5,447.90 |
Serine Protease Inhibitors
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79\u202fnM, 1580\u202fnM and 1330\u202fnM for human uPA, tPA, and plasmin, respectively. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Information ZK824859 ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively. Targets human uPA (Cell-free assay); human plasmin (Cell-free assay); human tPA (Cell-free assay) 79 nM; 1330 nM; 1580 nM |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2R)-2-[6-[3-[3-(aminomethyl)phenyl]-5-methylphenoxy]-3,5-difluoropyridin-2-yl]oxybutanoic acid |
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INCHI | InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1 |
InChi Key | CVNXUNVHFJANHX-HXUWFJFHSA-N |
Canonical SMILES | CCC(C(=O)O)OC1=C(C=C(C(=N1)OC2=CC(=CC(=C2)C3=CC=CC(=C3)CN)C)F)F |
Isomeric SMILES | CC[C@H](C(=O)O)OC1=C(C=C(C(=N1)OC2=CC(=CC(=C2)C3=CC=CC(=C3)CN)C)F)F |
PubChem CID | 69496820 |
Molecular Weight | 414.4 |
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Solubility | Solubility (25°C) In vitro DMSO: 86 mg/mL (207.52 mM); Ethanol: 86 mg/mL (207.52 mM); Water: Insoluble; |
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Starting at $248.90