ZK824859 - 99%, high purity , CAS No.2254001-81-3

  • ≥99%
Item Number
Z412413
Grouped product items
SKUSizeAvailabilityPrice Qty
Z412413-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,809.90
Z412413-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$5,447.90

Serine Protease Inhibitors

Basic Description

Specifications & Purity≥99%
Biochemical and Physiological MechanismsZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79\u202fnM, 1580\u202fnM and 1330\u202fnM for human uPA, tPA, and plasmin, respectively.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

ZK824859 ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.


Targets

human uPA (Cell-free assay); human plasmin (Cell-free assay); human tPA (Cell-free assay) 79 nM; 1330 nM; 1580 nM

Associated Targets(Human)

PLAU Tchem Urokinase-type plasminogen activator (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLG Tclin Plasminogen (2339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLAT Tclin Tissue-type plasminogen activator (1057 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLAU Tchem Urokinase-type plasminogen activator (2016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R)-2-[6-[3-[3-(aminomethyl)phenyl]-5-methylphenoxy]-3,5-difluoropyridin-2-yl]oxybutanoic acid
INCHI InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1
InChi Key CVNXUNVHFJANHX-HXUWFJFHSA-N
Canonical SMILES CCC(C(=O)O)OC1=C(C=C(C(=N1)OC2=CC(=CC(=C2)C3=CC=CC(=C3)CN)C)F)F
Isomeric SMILES CC[C@H](C(=O)O)OC1=C(C=C(C(=N1)OC2=CC(=CC(=C2)C3=CC=CC(=C3)CN)C)F)F
PubChem CID 69496820
Molecular Weight 414.4

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 86 mg/mL (207.52 mM); Ethanol: 86 mg/mL (207.52 mM); Water: Insoluble;

Related Documents

Solution Calculators