Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Z275221-10mg | 10mg | In stock | $107.90 | |
Z275221-25mg | 25mg | In stock | $243.90 | |
Z275221-50mg | 50mg | In stock | $391.90 | |
Z275221-100mg | 100mg | In stock | $608.90 |
Potent, selective A 2A antagonist
Synonyms | C16H15N7O2 | CHEBI:92361 | DB08770 | 5NIC36BO71 | GTPL405 | NCGC00024955-01 | BRD-K19605405-001-01-9 | MFCD00908394 | AC-32730 | AKOS024456344 | HMS3886P04 | SR-01000597469-1 | BCPP000003 | PDSP1_001201 | 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-(3-phenyl-1 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Potent A 2 adenosine receptor antagonist, with approx 50-fold selectivity for A 2A receptors. (K i values are <1 nM, 50 nM, 255 nM and >10 μM at human cloned A 2A , A 2B , A 1 and A 3 receptors, respectively). Orally active in vivo . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of A 1 receptor;Antagonist of A 2A receptor;Antagonist of A 2B receptor;Antagonist of A 3 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
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IUPAC Name | 4-[2-[[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]phenol |
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INCHI | InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) |
InChi Key | PWTBZOIUWZOPFT-UHFFFAOYSA-N |
Canonical SMILES | C1=COC(=C1)C2=NN3C(=NC(=NC3=N2)NCCC4=CC=C(C=C4)O)N |
Isomeric SMILES | C1=COC(=C1)C2=NN3C(=NC(=NC3=N2)NCCC4=CC=C(C=C4)O)N |
PubChem CID | 176407 |
Molecular Weight | 337.34 |
PubChem CID | 176407 |
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CAS Registry No. | 139180-30-6 |
ChEMBL Ligand | CHEMBL113142 |
DrugBank Ligand | DB08770 |
Wikipedia | ZM-241,385 |
RCSB PDB Ligand | ZMA |
GPCRdb Ligand | ZM-241385 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2423054 | Certificate of Analysis | Jul 30, 2024 | Z275221 |
I2202929 | Certificate of Analysis | Jun 13, 2023 | Z275221 |
I2202931 | Certificate of Analysis | Jun 13, 2023 | Z275221 |
I2202932 | Certificate of Analysis | Jun 05, 2023 | Z275221 |
I2202930 | Certificate of Analysis | Jun 05, 2023 | Z275221 |
Solubility | Soluble in DMSO to 100 mM and in ethanol to 5 mM (with warming) |
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Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
1. Basu M et al.. (2020) Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection.. J Cell Sci, 133 (7): [PMID:32079656] |