ZM 306416 - ≥98%, high purity , CAS No.690206-97-4, Inhibitor of epidermal growth factor receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor
ZM 306416 - ≥98%, high purity , CAS No.690206-97-4, Inhibitor of epidermal growth factor receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor
Description: IC50 Value: 0.67uM(for VEGFR); 0.33±0.08uM(for Src); 1.3±0.2 μM(for Abl) ZM-306416, a vascular endothelial growth factor receptor (VEGFR) antagonist, was identified as a potent inhibitor of EGFR function [2].
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of epidermal growth factor receptor;Inhibitor of fms related receptor tyrosine kinase 1;Inhibitor of kinase insert domain receptor
Note
卖完停产，不再备货
Product Description
ZM-306416(CB 676475) is a VEGFR inhibitor that inhibits Flk-1 (KDR) (IC50=100 nM) and Flt (IC50 =2 μM); displays 4-fold selectivity over FGFR-1; inhibitor of c-Abl, Flt-1 and Src
1.Hennequin LF, Thomas AP, Johnstone C, Stokes ES, Plé PA, Lohmann JJ, Ogilvie DJ, Dukes M, Wedge SR, Curwen JO et al.. (1999) Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.. J Med Chem, 42 (26):(5369-89). [PMID:10639280][10.1021/op500134e]
2.Antczak C, Mahida JP, Bhinder B, Calder PA, Djaballah H. (2012) A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.. J Biomol Screen, 17 (7):(885-99). [PMID:22573732][10.1021/op500134e]
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H1816136