ZM 336372 - ≥98%, high purity , CAS No.208260-29-1, Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase

Item Number

Z129624

• Synonyms: 208260-29-1 | ZM 336372 | ZM336372 | ZM-336372 | 3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide | N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide | CHEMBL186526 | n-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamid
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: ZM 336372 is a reversible, selective inhibitor of the protein kinase Raf-1 (IC50 = 70nM). Although ZM 336372 weakly inhibits Raf-B, it is 10 fold more potent against Raf-1 and so is considered more selective towards this kinase. ZM 336372 inhibits Raf-1 b
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc.
A potent and selective Raf-1 inhibitor.