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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Z129624-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $68.90 | |
Z129624-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $123.90 | |
Z129624-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $426.90 |
Potent, selective c-Raf inhibitor
Synonyms | 208260-29-1|ZM 336372|ZM336372|ZM-336372|3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide|N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide|CHEMBL186526|n-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamid |
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Specifications & Purity | ≥98% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase |
Product Description | ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide |
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INCHI | InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) |
InChi Key | PYEFPDQFAZNXLI-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O |
Isomeric SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O |
WGK Germany | 3 |
Alternate CAS | 208260-29-1 |
PubChem CID | 5730 |
MeSH Entry Terms | N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide;ZM 336372;ZM-336372;ZM336372 |
Molecular Weight | 389.45 |
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Lot Number | Certificate Type | Date | Item |
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E1520085 | Certificate of Analysis | Jan 17, 2023 | Z129624 |
Solubility | Soluble in DMSO (200 mg/ml), DMF (~20 mg/ml), water (0.5 mg/ml at 25 °C), and ethanol (2 mg/ml at 25 °C). |
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Sensitivity | Light sensitive |
WGK Germany | 3 |
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1. Brown DS, Belfield AJ, Brown GR, Campbell D, Foubister A, Masters DJ, Pike KG, Snelson WL, Wells SL. (2004) A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis.. Bioorg Med Chem Lett, 14 (21): (5383-7). [PMID:15454231] |