ZM 336372 - ≥98%, high purity , CAS No.208260-29-1, Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase

Item Number

Z129624

Grouped product items
SKU	Size	Availability	Price
Z129624-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$68.90
Z129624-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$123.90
Z129624-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$426.90

Potent, selective c-Raf inhibitor

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Basic Description

Synonyms	208260-29-1\|ZM 336372\|ZM336372\|ZM-336372\|3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide\|N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide\|CHEMBL186526\|n-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamid
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase
Product Description	ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc. A potent and selective Raf-1 inhibitor.

Names and Identifiers

IUPAC Name	3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide
INCHI	InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChi Key	PYEFPDQFAZNXLI-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O
Isomeric SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O
WGK Germany	3
Alternate CAS	208260-29-1
PubChem CID	5730
MeSH Entry Terms	N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide;ZM 336372;ZM-336372;ZM336372
Molecular Weight	389.45

Certificates

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Lot Number	Certificate Type	Date	Item
E1520085	Certificate of Analysis	Jan 17, 2023	Z129624

Solubility

Soluble in DMSO (200 mg/ml), DMF (~20 mg/ml), water (0.5 mg/ml at 25 °C), and ethanol (2 mg/ml at 25 °C).

Sensitivity

Light sensitive

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Basic Description