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ZM-447439 - ≥98%, high purity , CAS No.331771-20-1, Inhibitor of aurora kinase A;Inhibitor of aurora kinase B

  • Moligand™
  • ≥98%
Item Number
Z125121
Grouped product items
SKUSizeAvailabilityPrice Qty
Z125121-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$53.90
Z125121-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$75.90
Z125121-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$282.90
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Potent Aurora B kinase inhibitor

View related series
aurora kinase A Inhibitor aurora kinase B Inhibitor

Basic Description

Synonyms331771-20-1|ZM-447439|ZM 447439|ZM447439|N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE|N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide|TCMDC-125873|C29H31N5O4|CHEMBL202721|RSN3P9776R|Ben
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InDry ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of aurora kinase A;Inhibitor of aurora kinase B
Product Description

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
A selective inhibitor of ARK-1, ARK-2, and ARK-3.

Associated Targets

AURKA Tchem Aurora kinase A 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKB Tchem Aurora kinase B 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[4-[[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]phenyl]benzamide
INCHI InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
InChi Key OGNYUTNQZVRGMN-UHFFFAOYSA-N
Canonical SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
Isomeric SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
PubChem CID 9914412
Molecular Weight 513.59

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Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
B1626114Certificate of AnalysisJul 14, 2023 Z125121

Chemical and Physical Properties

SolubilitySoluble in DMSO (25 mg/ml), methanol, water (<1 mg/ml) at 25 °C, ethanol (48 mg/ml) at 25 °C, DMF (~20 mg/ml), and DMSO:PBS (1:1, pH 7.2) (~0.5 mg/ml).

Related Documents

 SDS

 Specification Sheet

References

1. Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS.  (2003)  Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores..  J Cell Biol,  161  (2): (267-80).  [PMID:12719470]

Solution Calculators

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