ZM-447439 - ≥98%, high purity , CAS No.331771-20-1, Inhibitor of aurora kinase A;Inhibitor of aurora kinase B

Item Number

Z125121

• Synonyms: (S)-1-(Benzyloxy)-2,3-epoxypropane | CS-0009 | N-[4-[[6-Methoxy-7-[3-(4-morpholiny l)propoxy]-4-quinazolinyl]amino]phenyl]benzamide | NCGC00159574-01 | NCGC00159574-09 | N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: ZM-447439 is a selective inhibitor of aurora kinases ARK-1 (A) (IC50=1000 nM, Ki=100nM), ARK-2 (B) (IC50= 50 nM, Ki= 0.36 nM) and ARK-3 (C), that can induce growth arrest, inhibit histone H3 phosphorylation and effectively activate apoptosis. The compound
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of aurora kinase A;Inhibitor of aurora kinase B
• Note: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Product Description

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
A selective inhibitor of ARK-1, ARK-2, and ARK-3.