Zolbetuximab (anti-CLDN18.2) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to CLDN18, >95%, high purity, Human IgG1, Antibody of claudin 18
Zolbetuximab (anti-CLDN18.2) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to CLDN18, >95%, high purity, Human IgG1, Antibody of claudin 18
Zolbetuximab (anti-CLDN18.2) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to CLDN18, >95%, high purity, Human IgG1
Zolbetuximab is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates the specific killing of Claudin-18.2-positive cells through an immune mechanism. Zolbetuximab can be used in the study of gastrointestinal adenocarcinoma and pancreatic tumors.
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Product Properties
Antibody Type
Primary antibody
Clonality
Recombinant
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
27.3 kDa (Light Chain) & 52.1 kDa (Heavy Chain), under reducing conditions; 181.8 kDa, under non-reducing conditions.
Purification Method
Protein A purified
Purity
>95%
Source
CHO supernatant
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
1496553-00-4
Images
Zolbetuximab (anti-CLDN18.2) (Ab170589) - SEC The purity of Zolbetuximab (anti-CLDN18.2) (Ab170589) is more than 95% verified by HPLC.
1.Sahin U, Koslowski M, Dhaene K, Usener D, Brandenburg G, Seitz G, Huber C, Türeci O. (2008) Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.. Clin Cancer Res, 14 (23):(7624-34). [PMID:19047087][10.1021/op500134e]
2.Wöll S, Schlitter AM, Dhaene K, Roller M, Esposito I, Sahin U, Türeci Ö. (2014) Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms.. Int J Cancer, 134 (3):(731-9). [PMID:23900716][10.1021/op500134e]
3.Athauda A, Chau I. (2021) Claudin 18.2-a FAST-moving target in gastric cancer?. Ann Oncol, 32 (5):(584-586). [PMID:33677015][10.1021/op500134e]
4.Kyuno D, Takasawa A, Takasawa K, Ono Y, Aoyama T, Magara K, Nakamori Y, Takemasa I, Osanai M. (2022) Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials.. Tissue Barriers, 10 (1):(1967080). [PMID:34486479][10.1021/op500134e]
5.Cao W, Xing H, Li Y, Tian W, Song Y, Jiang Z, Yu J. (2022) Claudin18.2 is a novel molecular biomarker for tumor-targeted immunotherapy.. Biomark Res, 10 (1):(38). [PMID:35642043][10.1021/op500134e]
6.Niimi, T T and 6 more authors.. (2001) claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.. Molecular and cellular biology, [PMID:11585919]
7.LaFemina, Michael J MJ and 10 more authors.. (2014) Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.. American journal of respiratory cell and molecular biology, [PMID:24787463]
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