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Zoledronic Acid - ≥99%, high purity , Farnesyl diphosphate synthase inhibitor, CAS No.118072-93-8, Farnesyl diphosphate synthase inhibitor
Highly potent bisphosphonate. FPP synthase inhibitor.
Basic Description Synonyms Zoledronic acid|118072-93-8|Zoledronate|Zometa|Reclast|Aclasta|(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid|CGP 42446|(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid|Zoledronic Acid Anhydrous|C5H10N2O7P2|Anhydrous Zoledronic Aci Specifications & Purity ≥99% Storage Temp Store at -20°C Shipped In Dry ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Farnesyl diphosphate synthase inhibitor
Names and Identifiers Pubchem Sid 488184180 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488184180 IUPAC Name (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid INCHI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14) InChi Key XRASPMIURGNCCH-UHFFFAOYSA-N Canonical SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O Isomeric SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O PubChem CID 68740 Molecular Weight 272.09
Chemical and Physical Properties Solubility DMSO 0.004 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H317: May cause an allergic skin reaction
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
References 1. Lu H et al.. (2021) B7-H3 confers resistance to V?9Vd2 T cell-mediated cytotoxicity in human colon cancer cells via the STAT3/ULBP2 axis.. Cancer Immunol Immunother, 70 (5): (1213-1226). [PMID:33119798 ] 2. Lu H et al.. (2020) B7-H3 inhibits the IFN-?-dependent cytotoxicity of V?9Vd2 T cells against colon cancer cells.. Oncoimmunology, 9 (1748991). [PMID:32363121 ]
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H2406230