Zoledronic Acid - ≥99%, high purity , Farnesyl diphosphate synthase inhibitor, CAS No.118072-93-8, Farnesyl diphosphate synthase inhibitor

3 Citations
Item Number
Z129382
Grouped product items
SKUSizeAvailabilityPrice Qty
Z129382-25mg
25mg
In stock
$9.90
Z129382-100mg
100mg
In stock
$14.90
Z129382-1g
1g
In stock
$28.90
Z129382-5g
5g
In stock
$98.90
Z129382-25g
25g
In stock
$444.90

Highly potent bisphosphonate. FPP synthase inhibitor.

Basic Description

Synonyms70HZ18PH24 | CAS-118072-93-8 | SR-05000001436 | (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid | D08689 | FT-0601384 | GTPL3177 | NCGC00159521-02 | s1314 | AB01273947-03 | 1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid | AB01
Specifications & Purity≥99%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionFarnesyl diphosphate synthase inhibitor

Product Properties

ALogP-4.3

Associated Targets(Human)

FDPS Tclin Farnesyl pyrophosphate synthase (29 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA12 Tclin Carbonic anhydrase 12 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA14 Tclin Carbonic anhydrase 14 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BTN3A1 Tchem Butyrophilin subfamily 3 member A1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488184180
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184180
IUPAC Name (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
INCHI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
InChi Key XRASPMIURGNCCH-UHFFFAOYSA-N
Canonical SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
Isomeric SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
PubChem CID 68740
Molecular Weight 272.09

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

20 results found

Lot NumberCertificate TypeDateItem
H2406230Certificate of AnalysisMar 02, 2024 Z129382
G23221028Certificate of AnalysisJul 07, 2023 Z129382
H2429022Certificate of AnalysisJul 07, 2023 Z129382
G23221042Certificate of AnalysisJul 07, 2023 Z129382
G23221041Certificate of AnalysisJul 07, 2023 Z129382
G23221040Certificate of AnalysisJul 07, 2023 Z129382
G23221038Certificate of AnalysisJul 07, 2023 Z129382
G23221037Certificate of AnalysisJul 07, 2023 Z129382
G23221034Certificate of AnalysisJul 07, 2023 Z129382
G23221033Certificate of AnalysisJul 07, 2023 Z129382
G23221017Certificate of AnalysisJul 07, 2023 Z129382
C2415131Certificate of AnalysisJul 07, 2023 Z129382
C2130027Certificate of AnalysisJan 12, 2023 Z129382
C2130026Certificate of AnalysisJan 12, 2023 Z129382
C2130024Certificate of AnalysisJan 12, 2023 Z129382
D1912082Certificate of AnalysisDec 06, 2022 Z129382
F2230307Certificate of AnalysisJul 04, 2022 Z129382
F2215113Certificate of AnalysisJun 23, 2022 Z129382
E2312259Certificate of AnalysisJun 23, 2022 Z129382
C2011020Certificate of AnalysisJan 27, 2022 Z129382

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Chemical and Physical Properties

SolubilityDMSO 0.004 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H319:Causes serious eye irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

Related Documents

Citations of This Product

1. Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang.  (2024)  Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis.  Journal of the Mechanical Behavior of Biomedical Materials,  150  (106306).  [PMID:38091923]
2. Yao Duan, Chanyuan Jin, Yuwei Wu, Yan Chen, Minjuan Zhang, Jun Qian, Ting Shuai, Jian Li, Huimin Chen, Dan Li.  (2023)  CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF.  TISSUE & CELL,  85  (1): (102223).  [PMID:37776785]
3. Ting Ge, Zhang Weiwei, Fei Ge, Longbao Zhu, Ping Song, Wanzheng Li, Lin Gui, Wan Dong, Yugui Tao, Kai Yang.  (2022)  A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis.  Biomaterials Science,  10  (7): (1831-1843).  [PMID:35253030]

References

1. Lu H et al..  (2021)  B7-H3 confers resistance to V?9Vd2 T cell-mediated cytotoxicity in human colon cancer cells via the STAT3/ULBP2 axis..  Cancer Immunol Immunother,  70  (5): (1213-1226).  [PMID:33119798]
2. Lu H et al..  (2020)  B7-H3 inhibits the IFN-?-dependent cytotoxicity of V?9Vd2 T cells against colon cancer cells..  Oncoimmunology,  (1748991).  [PMID:32363121]
3. Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang.  (2024)  Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis.  Journal of the Mechanical Behavior of Biomedical Materials,  150  (106306).  [PMID:38091923]
4. Yao Duan, Chanyuan Jin, Yuwei Wu, Yan Chen, Minjuan Zhang, Jun Qian, Ting Shuai, Jian Li, Huimin Chen, Dan Li.  (2023)  CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF.  TISSUE & CELL,  85  (1): (102223).  [PMID:37776785]
5. Ting Ge, Zhang Weiwei, Fei Ge, Longbao Zhu, Ping Song, Wanzheng Li, Lin Gui, Wan Dong, Yugui Tao, Kai Yang.  (2022)  A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis.  Biomaterials Science,  10  (7): (1831-1843).  [PMID:35253030]

Solution Calculators