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Z140117-1g

In stock

$35.90

Z140117-5g

Available within 4-8 weeks(?)

$88.90

Z140117-25g

25g

Available within 4-8 weeks(?)

$397.90

Basic Description

Synonyms	CGP-42446A \| ZOLEDRONIC ACID [USP MONOGRAPH] \| Tox21_112486 \| Zoledronate hydrate \| Zoledronate monohydrate;CGP 42446 monohydrate;CGP42446A monohydrate;ZOL 446 monohydrate \| Zoledronic acid monohydrate, >=98% (HPLC) \| Zoledronic Acid Teva Pharma \| CCG-222
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Zoledronic acid monohydrate, also known as cgp 42'446, is a heterocyclic bisphosphonate that is considered to have the highest potency of bisphosphonates for suppression of increased bone resorption and has been used in several osteoporosis studies. The c
Storage Temp	Protected from light,Room temperature
Shipped In	Normal
Product Description	Zoledronic acid monohydrate(CGP 42446; ZOL 446) is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 uM. A highly potent bisphosphonate and activator of PKC.

Associated Targets(Human)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

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FDPS Tclin Farnesyl diphosphate synthase (1240 Activities)

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GGPS1 Tchem Geranylgeranyl pyrophosphate synthetase (715 Activities)

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CA1 Tclin Carbonic anhydrase I (13240 Activities)

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CA14 Tclin Carbonic anhydrase XIV (1305 Activities)

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MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

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MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)

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CA12 Tclin Carbonic anhydrase XII (6231 Activities)

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CA9 Tclin Carbonic anhydrase IX (8255 Activities)

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Homo sapiens (32628 Activities)

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BXPC-3 (2997 Activities)

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CCRF-CEM (65223 Activities)

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CFPAC-1 (421 Activities)

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K562 (73714 Activities)

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LoVo (4724 Activities)

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MCF7 (126967 Activities)

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MG-63 (795 Activities)

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PANC-1 (6144 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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SiHa (2051 Activities)

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MIA PaCa-2 (5949 Activities)

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HCT-116 (91556 Activities)

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HFF (3142 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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HuT78 (515 Activities)

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HUVEC (11049 Activities)

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KB (17409 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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BT-549 (31254 Activities)

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

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ABCB11 Tchem Bile salt export pump (2311 Activities)

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ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)

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Ca-Ski (420 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)

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Hydroxyapatite (165 Activities)

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BTN3A1 Tchem Butyrophilin subfamily 3 member A1 (291 Activities)

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Associated Targets(non-human)

Abcc1 Multidrug resistance-associated protein 1 (42 Activities)

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Mmp2 Matrix metalloproteinase-2 (12 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Geranyltranstransferase (9 Activities)

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Escherichia coli (133304 Activities)

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Entamoeba histolytica (2676 Activities)

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Plasmodium falciparum (966862 Activities)

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Trypanosoma cruzi (99888 Activities)

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Toxoplasma gondii (4585 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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Dictyostelium discoideum (81 Activities)

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J774.A1 (2436 Activities)

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RAW264.7 (28094 Activities)

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J774 (3120 Activities)

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PPase1 Vacuolar-type proton translocating pyrophosphatase 1 (115 Activities)

Discover Target: PPase1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Farnesyl pyrophosphate synthase (85 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BTS1 Geranylgeranyl pyrophosphate synthase (17 Activities)

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MC3T3-E1 (421 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid;hydrate
INCHI	InChI=1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChi Key	FUXFIVRTGHOMSO-UHFFFAOYSA-N
Canonical SMILES	C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O
Isomeric SMILES	C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O
WGK Germany	3
Alternate CAS	165800-06-6
PubChem CID	121586
MeSH Entry Terms	2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid;CGP 42'446;CGP 42446;CGP 42446A;CGP-42'446;CGP-42446;CGP42'446;CGP42446;zoledronate;zoledronic acid;zoledronic acid anhydrous;Zometa
Molecular Weight	290.1

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
F2308468	Certificate of Analysis	Jun 16, 2023	Z140117
F2308473	Certificate of Analysis	Jun 16, 2023	Z140117
F2308474	Certificate of Analysis	Jun 16, 2023	Z140117
E23301266	Certificate of Analysis	May 22, 2023	Z140117
E23301277	Certificate of Analysis	May 22, 2023	Z140117
E23301301	Certificate of Analysis	May 22, 2023	Z140117

Chemical and Physical Properties

Solubility	Soluble in water (7 mg/ml), 0.1N NaOH, methanol (0.12 mg/ml at 25 °C), and ethanol (0.13 mg/ml at 25 °C).
Sensitivity	Moisture & Light & Heat sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jiang Yingying, Tao Yali, Chen Yutong, Xue Xu, Ding Gangyi, Wang Sicheng, Liu Guodong, Li Mengmeng, Su Jiacan. (2022) Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35813995] [10.3389/fbioe.2022.875531]

References

1. Jiang Yingying, Tao Yali, Chen Yutong, Xue Xu, Ding Gangyi, Wang Sicheng, Liu Guodong, Li Mengmeng, Su Jiacan. (2022) Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy. Frontiers in Bioengineering and Biotechnology, 10 [PMID:35813995] [10.3389/fbioe.2022.875531]

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Zoledronic Acid Monohydrate - ≥98%(HPLC), high purity , CAS No.165800-06-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator