Skip to the beginning of the images gallery

Zosuquidar trihydrochloride - ≥99%, high purity , CAS No.167465-36-3

≥99%

CAS#: 167465-36-3
Formula: C₃₂H₃₁F₂N₃O₂.3HCl
Molecular Weight: 637
PubChem CID: 153997

Item Number

L126616

Grouped product items
SKU	Size	Availability	Price
L126616-5mg	5mg	In stock	$59.90
L126616-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$79.90
L126616-25mg	25mg	In stock	$159.90
L126616-50mg	50mg	In stock	$249.90
L126616-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$379.90

High affinity P-gp inhibitor

Basic Description

Synonyms	ZOSUQUIDAR TRIHYDROCHLORIDE [MI] \| Tox21_113964 \| Zosuquidar Trihydrochloride [USAN] \| LY335979 trihydrochloride \| LY-335979 trihydrochloride \| NSC-725086 \| T71107 \| EX-A2191 \| (R)-1-(4-((1aR,6r,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopro
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	High affinity P-glycoprotein (P-gp) inhibitor (Kd= 79 nM). Restoresdoxorubicin sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy oftaxol in a MDR human non-small cell lung carcinoma xenograft m
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. A modulator of Pgp.

Associated Targets(Human)

ABCB1 Tchem Multidrug resistance protein 1 (6 Activities)

Discover Target: ABCB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (0 Activities)

Discover Target: ABCC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

Discover Target: ABCC2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero C1008 (1716 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2R)-1-[4-[(2R,4S)-3,3-difluoro-11-tetracyclo[10.4.0.02,4.05,10]hexadeca-1(16),5,7,9,12,14-hexaenyl]piperazin-1-yl]-3-quinolin-5-yloxypropan-2-ol;trihydrochloride
INCHI	InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29-,30+,31?;;;/m1.../s1
InChi Key	ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
Canonical SMILES	C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5C6C(C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl
Isomeric SMILES	C1CN(CCN1C[C@H](COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5[C@H]6[C@H](C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl
Alternate CAS	167354-41-8
PubChem CID	153997
Molecular Weight	637

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
B23211024	Certificate of Analysis	Nov 25, 2022	L126616
B23211027	Certificate of Analysis	Nov 25, 2022	L126616
B23211125	Certificate of Analysis	Nov 25, 2022	L126616
B2321944	Certificate of Analysis	Nov 25, 2022	L126616
B2322011	Certificate of Analysis	Nov 25, 2022	L126616
H2427410	Certificate of Analysis	Sep 15, 2021	L126616
H2427412	Certificate of Analysis	Sep 15, 2021	L126616
H2427413	Certificate of Analysis	Sep 15, 2021	L126616
H2427414	Certificate of Analysis	Sep 15, 2021	L126616
H2427415	Certificate of Analysis	Sep 15, 2021	L126616
H2427416	Certificate of Analysis	Sep 15, 2021	L126616

Show more⌵

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.