Zosuquidar trihydrochloride - ≥99%, high purity , CAS No.167465-36-3

Item Number

L126616

Grouped product items
SKU	Size	Availability	Price
L126616-5mg	5mg	In stock	$59.90
L126616-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$79.90
L126616-25mg	25mg	In stock	$159.90
L126616-50mg	50mg	In stock	$249.90
L126616-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$379.90

High affinity P-gp inhibitor

Basic Description

Synonyms	Zosuquidar Trihydrochloride\|167465-36-3\|Ly335979\|Zosuquidar HCl\|RS-33295-198\|LY 335979\|Zosuquidar 3HCl\|Zosuquidar (LY335979) 3HCl\|LY335979 (Zosuquidar 3HCL)\|Zosuquidar (trihydrochloride)\|LY-335979\|Zosuquidar Trihydrochloride [USAN]\|LY335979 trihydrochlori
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	High affinity P-glycoprotein (P-gp) inhibitor (Kd= 79 nM). Restoresdoxorubicin sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy oftaxol in a MDR human non-small cell lung carcinoma xenograft m
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. A modulator of Pgp.

Names and Identifiers

IUPAC Name	(2R)-1-[4-[(2R,4S)-3,3-difluoro-11-tetracyclo[10.4.0.02,4.05,10]hexadeca-1(16),5,7,9,12,14-hexaenyl]piperazin-1-yl]-3-quinolin-5-yloxypropan-2-ol;trihydrochloride
INCHI	InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29-,30+,31?;;;/m1.../s1
InChi Key	ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
Canonical SMILES	C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5C6C(C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl
Isomeric SMILES	C1CN(CCN1C[C@H](COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5[C@H]6[C@H](C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl
Alternate CAS	167354-41-8
PubChem CID	153997
Molecular Weight	637

Certificates

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11 results found

Lot Number	Certificate Type	Date	Item
B23211024	Certificate of Analysis	Nov 25, 2022	L126616
B23211027	Certificate of Analysis	Nov 25, 2022	L126616
B23211125	Certificate of Analysis	Nov 25, 2022	L126616
B2321944	Certificate of Analysis	Nov 25, 2022	L126616
B2322011	Certificate of Analysis	Nov 25, 2022	L126616
H2427410	Certificate of Analysis	Sep 15, 2021	L126616
H2427412	Certificate of Analysis	Sep 15, 2021	L126616
H2427413	Certificate of Analysis	Sep 15, 2021	L126616
H2427414	Certificate of Analysis	Sep 15, 2021	L126616
H2427415	Certificate of Analysis	Sep 15, 2021	L126616
H2427416	Certificate of Analysis	Sep 15, 2021	L126616

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Solution Calculators

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Basic Description