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Zotepine - 98%(HPLC), high purity , CAS No.26615-21-4, Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 1B receptor;Antagonist of 5-HT 1D receptor;Antagonist of 5-ht 1e receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor;Antagonis

Moligand™
≥98%(HPLC)

CAS#: 26615-21-4
Formula: C₁₈H₁₈ClNOS
Molecular Weight: 331.86
MDL number: MFCD00868143
PubChem CID: 5736
PubChem SID: 488179919

Item Number

Z132909

Grouped product items
SKU	Size	Availability	Price
Z132909-10mg	10mg	In stock	$187.90
Z132909-50mg	50mg	In stock	$642.90
Z132909-250mg	250mg	In stock	$2,893.90
Z132909-1g	1g	In stock	$10,416.90
Z132909-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$46,874.90

View related series

5-HT1A receptor Antagonist 5-HT1B receptor Antagonist 5-HT1D receptor Antagonist 5-ht1e receptor Antagonist 5-HT2A receptor Antagonist 5-HT2C receptor Antagonist 5-HT6 receptor Antagonist 5-HT7 receptor Antagonist D2 receptor Antagonist D3 receptor Antagonist D4 receptor Antagonist H1 receptor Antagonist NET Inhibitor SERT Inhibitor α2B-adrenoceptor Antagonist

Basic Description

Synonyms	zotepine\|26615-21-4\|Nipolept\|Lodopin\|Zoleptil\|Zotepina\|Zotepinum\|Setous\|Zotepin\|2-Chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin\|Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-\|2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-
Specifications & Purity	Moligand™, ≥98%(HPLC)
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	ANTAGONIST, INHIBITOR
Mechanism of action	Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 1B receptor;Antagonist of 5-HT 1D receptor;Antagonist of 5-ht 1e receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor;Antagonis

Names and Identifiers

Pubchem Sid	488179919
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179919
IUPAC Name	2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethylethanamine
INCHI	InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
InChi Key	HDOZVRUNCMBHFH-UHFFFAOYSA-N
Canonical SMILES	CN(C)CCOC1=CC2=CC=CC=C2SC3=C1C=C(C=C3)Cl
Isomeric SMILES	CN(C)CCOC1=CC2=CC=CC=C2SC3=C1C=C(C=C3)Cl
WGK Germany	3
PubChem CID	5736
Molecular Weight	331.86

PubChem CID

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CAS Registry No.

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ChEMBL Ligand

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RCSB PDB Ligand

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2 results found

Lot Number	Certificate Type	Date	Item
F2004184	Certificate of Analysis	Jan 23, 2024	Z132909
L2209216	Certificate of Analysis	Dec 30, 2022	Z132909

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

References

1. Shobo M, Kondo Y, Yamada H, Mihara T, Yamamoto N, Katsuoka M, Harada K, Ni K, Matsuoka N. (2010) Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake.. J Pharmacol Exp Ther, 333 (3): (772-81). [PMID:20223878]

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