cGMP-dependent protein kinase 1 beta
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ID: ALA4273
Type: SINGLE PROTEIN
Synonyms: 2.7.11.12 | cGK 1 | cGK1 | cGKI | cGMP-dependent protein kinase 1 | cGMP-dependent protein kinase I | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B
Organism: Homo sapiens
Species Group: Homo sapiens
Protein Target Classification: Enzyme / Kinase / Protein Kinase / AGC protein kinase group / AGC protein kinase PKG family
Description | Relationship | Accession |
---|---|---|
cGMP-dependent protein kinase 1 | PROTEIN | Q13976 |
Name:
(2S,3S)-1-((1H-Imidazol-2-yl)methyl)-3-((3,5-dichlorobenzyl)oxy)-2-phenylpiperidine
Mol. Formula:
C22H23Cl2N3O
M.W.:
416.35
Type:
Unknown
AlogP:
5.64
Polar Surface Area:
41.15
HBA:
3
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.57
Name:
2-(((2S,3S)-1-(4-(2H-tetrazol-5-yl)benzyl)-2-phenylpiperidin-3-yl)oxy)-2-(3,5-dichlorophenyl)ethan-1-ol
Mol. Formula:
C27H27Cl2N5O2
M.W.:
524.45
Type:
Unknown
AlogP:
5.63
Polar Surface Area:
87.16
HBA:
6
HBD:
2
#RO5 Violations:
2
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.31
Name:
5-(((2S,3S)-3-((3,5-dichlorobenzyl)oxy)-2-phenylpiperidin-1-yl)methyl)picolinic acid
Mol. Formula:
C25H24Cl2N2O3
M.W.:
471.38
Type:
Unknown
AlogP:
6.01
Polar Surface Area:
62.66
HBA:
4
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.46
Name:
5-(((2S,3S)-3-(1-(3,5-dichlorophenyl)-2-hydroxyethoxy)-2-phenylpiperidin-1-yl)methyl)nicotinic acid
Mol. Formula:
C26H26Cl2N2O4
M.W.:
501.41
Type:
Unknown
AlogP:
5.54
Polar Surface Area:
82.89
HBA:
5
HBD:
2
#RO5 Violations:
2
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.42
Name:
(S)-2-(3,5-dichlorophenyl)-2-(((2S,3S)-1-methyl-2-phenylpiperidin-3-yl)oxy)ethan-1-ol
Mol. Formula:
C20H23Cl2NO2
M.W.:
380.32
Type:
Unknown
AlogP:
4.88
Polar Surface Area:
32.70
HBA:
3
HBD:
1
#RO5 Violations:
0
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.80
Name:
(2S,3S)-3-((3,5-dichlorobenzyl)oxy)-1-((1-methyl-1H-pyrazol-4-yl)methyl)-2-phenylpiperidine
Mol. Formula:
C23H25Cl2N3O
M.W.:
430.38
Type:
Unknown
AlogP:
5.65
Polar Surface Area:
30.29
HBA:
4
HBD:
0
#RO5 Violations:
1
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.51
Name:
2-(((2S,3S)-3-((3,5-dichlorobenzyl)oxy)-2-phenylpiperidin-1-yl)methyl)pyridine
Mol. Formula:
C24H24Cl2N2O
M.W.:
427.38
Type:
Unknown
AlogP:
6.31
Polar Surface Area:
25.36
HBA:
3
HBD:
0
#RO5 Violations:
1
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.46
Name:
(2S,3S)-3-((3,5-dichlorobenzyl)oxy)-1-methyl-2-phenylpiperidine
Mol. Formula:
C19H21Cl2NO
M.W.:
350.29
Type:
Unknown
AlogP:
5.35
Polar Surface Area:
12.47
HBA:
2
HBD:
0
#RO5 Violations:
1
#Rotatable Bonds:
4
Passes Ro3:
N
QED Weighted:
0.74
Name:
(2S,3S)-3-((3,5-dichlorobenzyl)oxy)-1-((1-methyl-1H-imidazol-2-yl)methyl)-2-phenylpiperidine
Mol. Formula:
C23H25Cl2N3O
M.W.:
430.38
Type:
Unknown
AlogP:
5.65
Polar Surface Area:
30.29
HBA:
4
HBD:
0
#RO5 Violations:
1
#Rotatable Bonds:
6
Passes Ro3:
N
QED Weighted:
0.51
Name:
2-(((2S,3S)-1-((1H-imidazol-2-yl)methyl)-2-phenylpiperidin-3-yl)oxy)-2-(3,5-dichlorophenyl)ethanol
Mol. Formula:
C23H25Cl2N3O2
M.W.:
446.38
Type:
Unknown
AlogP:
5.17
Polar Surface Area:
61.38
HBA:
4
HBD:
2
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.53