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Histone-lysine N-methyltransferase SETD7

Name And Classification

ID:  ALA5523

Type:  SINGLE PROTEIN

Synonyms:   2.1.1.364 | H3-K4-HMTase SETD7 | Histone H3-K4 methyltransferase SETD7 | Histone-lysine N-methyltransferase SETD7 | KIAA1717 | KMT7 | Lysine N-methyltransferase 7 | SET domain-containing protein 7 | SET7 | SET7/9 | SET9 | SET9 GN | SETD7 | Synonyms=KIAA1717

Organism:  Homo sapiens

Species Group:  Homo sapiens

Protein Target Classification:   Epigenetic regulator / Writer / Protein methyltransferase / SET domain

Target Components

DescriptionRelationshipAccession
Histone-lysine N-methyltransferase SETD7PROTEINQ8WTS6

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Active Ligands

  1. Tetrahydrouridine
    ALA1288492

    Name:
    (S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(2-(phenethylamino)ethyl)amino)butanoic acid

    Mol. Formula:
    C24H34N8O5

    M.W.:
    514.59

    Type:
    Small molecule

    AlogP:
    -1.04

    Polar Surface Area:
    197.90

    HBA:
    12

    HBD:
    6

    #RO5 Violations:
    3

    #Rotatable Bonds:
    13

    Passes Ro3:
    N

    QED Weighted:
    0.15

    DETAILS
  2. Tetrahydrouridine
    ALA1290415

    Name:
    (S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(2-(methylamino)ethyl)amino)butanoic acid

    Mol. Formula:
    C17H28N8O5

    M.W.:
    424.46

    Type:
    Small molecule

    AlogP:
    -2.65

    Polar Surface Area:
    197.90

    HBA:
    12

    HBD:
    6

    #RO5 Violations:
    2

    #Rotatable Bonds:
    10

    Passes Ro3:
    N

    QED Weighted:
    0.23

    DETAILS
  3. Tetrahydrouridine
    ALA1290416

    Name:
    (S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(2-(propylamino)ethyl)amino)butanoic acid

    Mol. Formula:
    C19H32N8O5

    M.W.:
    452.52

    Type:
    Small molecule

    AlogP:
    -1.87

    Polar Surface Area:
    197.90

    HBA:
    12

    HBD:
    6

    #RO5 Violations:
    2

    #Rotatable Bonds:
    12

    Passes Ro3:
    N

    QED Weighted:
    0.20

    DETAILS
  4. Tetrahydrouridine
    ALA1290525

    Name:
    (S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(2-(hexylamino)ethyl)amino)butanoic acid

    Mol. Formula:
    C22H38N8O5

    M.W.:
    494.60

    Type:
    Small molecule

    AlogP:
    -0.70

    Polar Surface Area:
    197.90

    HBA:
    12

    HBD:
    6

    #RO5 Violations:
    2

    #Rotatable Bonds:
    15

    Passes Ro3:
    N

    QED Weighted:
    0.17

    DETAILS
  5. Tetrahydrouridine
    ALA1290526

    Name:
    (S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(hexyl)amino)butanoic acid

    Mol. Formula:
    C20H33N7O5

    M.W.:
    451.53

    Type:
    Small molecule

    AlogP:
    -0.29

    Polar Surface Area:
    185.87

    HBA:
    11

    HBD:
    5

    #RO5 Violations:
    1

    #Rotatable Bonds:
    12

    Passes Ro3:
    N

    QED Weighted:
    0.27

    DETAILS
  6. Tetrahydrouridine
    ALA3238417

    Name:
    (S)-4-(3-(5-Bromo-1H-indol-1-yl)benzylthio)-2-aminobutanoic acid

    Mol. Formula:
    C19H19BrN2O2S

    M.W.:
    419.34

    Type:
    Small molecule

    AlogP:
    4.43

    Polar Surface Area:
    68.25

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    0

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.56

    DETAILS
  7. Tetrahydrouridine
    ALA3238418

    Name:
    4-(3-(5-Bromo-1H-indol-1-yl)benzylthio)butanoic acid

    Mol. Formula:
    C19H18BrNO2S

    M.W.:
    404.33

    Type:
    Small molecule

    AlogP:
    5.49

    Polar Surface Area:
    42.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.53

    DETAILS
  8. Tetrahydrouridine
    ALA3238419

    Name:
    3-(3-(5-Bromo-1H-indol-1-yl)benzylthio)benzoic acid

    Mol. Formula:
    C22H16BrNO2S

    M.W.:
    438.35

    Type:
    Small molecule

    AlogP:
    6.38

    Polar Surface Area:
    42.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.37

    DETAILS
  9. Tetrahydrouridine
    ALA3238420

    Name:
    3-(3-(4-Bromo-1H-indol-1-yl)benzylthio)benzoic acid

    Mol. Formula:
    C22H16BrNO2S

    M.W.:
    438.35

    Type:
    Small molecule

    AlogP:
    6.38

    Polar Surface Area:
    42.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.37

    DETAILS
  10. Tetrahydrouridine
    ALA3238421

    Name:
    3-(3-(4-Phenyl-1H-indol-1-yl)benzylthio)benzoic acid

    Mol. Formula:
    C28H21NO2S

    M.W.:
    435.55

    Type:
    Small molecule

    AlogP:
    7.29

    Polar Surface Area:
    42.23

    HBA:
    3

    HBD:
    1

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.28

    DETAILS