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EED

DescriptionPolycomb protein EED

Gene and Protein Information

Gene ID8726
Uniprot Accession IDs A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 hEED
Ensembl ID ENSP00000263360
Symbol HEED COGIS WAIT1
FamilyBelongs to the WD repeat ESC family.
Sequence
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque703866EEDembryonic ectoderm development9544Inparanoid, OMA, EggNOG
Mouse13626Eedembryonic ectoderm development10090MGI:95286Inparanoid, OMA, EggNOG
Rat293104Eedembryonic ectoderm development10116RGD:1309782Inparanoid, OMA, EggNOG
Dog476779EEDembryonic ectoderm development9615VGNC:40206Inparanoid, OMA, EggNOG
Horse100061139EEDembryonic ectoderm development9796VGNC:17428Inparanoid, OMA, EggNOG
Cow404183EEDembryonic ectoderm development9913VGNC:28332Inparanoid, OMA, EggNOG
Pig100521029EEDembryonic ectoderm development9823OMA, EggNOG
Opossum100026010EEDembryonic ectoderm development13616Inparanoid, OMA, EggNOG
Platypus100080634EEDembryonic ectoderm development9258Inparanoid, OMA, EggNOG
Chicken426381MIR6755microRNA 67559031CGNC:10494Inparanoid, OMA
Anole lizard100566610eedembryonic ectoderm development28377Inparanoid, OMA, EggNOG
Xenopus550079eedembryonic ectoderm development8364XB-GENE-491480Inparanoid, OMA, EggNOG
Zebrafish550463eedembryonic ectoderm development7955ZDB-GENE-050417-287Inparanoid, OMA
C. elegans177657mes-6Polycomb protein mes-66239Inparanoid, OMA, EggNOG
Fruitfly34595escextra sexcombs7227FBgn0000588Inparanoid, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

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    Associated Active Ligands

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    1. A-395Tetrahydrouridine

      RETTchemnull

      Ki p: 9.39

    2. 8-(6-Cyclopropylpyridin-3-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amineTetrahydrouridine

      RETTchemnull

      IC50 p: 9.70

    3. 8-(6-(Difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amineTetrahydrouridine

      RETTchemnull

      IC50 p: 9.70

    4. 12-(((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-4-isopropyl-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,8,11,12a-pentaozabenzo[4,5]cycloocta[1,2,3-cd]inden-3-oneTetrahydrouridine

      RETTchemnull

      IC50 p: 9.70

    5. rac-1-(4-(4-((3S,4R)-4-(dimethylamino)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)pyrrolidin-3-yl)phenyl)piperazin-1-yl)ethanoneTetrahydrouridine

      RETTchemnull

      Ki p: 9.54

    6. 1-(4-(4-((3S,4R)-4-(dimethylamino)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)pyrrolidin-3-yl)phenyl)piperazin-1-yl)ethanoneTetrahydrouridine

      RETTchemnull

      Ki p: 9.54

    7. rac-(1S,2R)-4-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-2-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)cyclopentanamineTetrahydrouridine

      RETTchemnull

      Ki p: 9.52

    8. 1-(4-(4-((3S,4R)-4-(Dimethylamino)-1-((S)-7-fluoro-2,3-dihydro-1H-inden-1-yl)pyrrolidin-3-yl)phenyl)piperazin-1-yl)ethanoneTetrahydrouridine

      RETTchemnull

      Ki p: 9.52

    9. (3R,4S)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amineTetrahydrouridine

      RETTchemnull

      Ki p: 9.52

    10. N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-1-(methylsulfonyl)-8-(6-(trifluoromethyl)pyridin-3-yl)imidazo[1,5-c]pyrimidin-5-amineTetrahydrouridine

      RETTchemnull

      IC50 p: 9.52

    Associated Diseases

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    NameDirect Associated TargetsDisease TypeMondoid